Background and Aims. Acute liver failure (ALF) is a severe syndrome with an elevated mortality rate, ranging from 40 to 80\n%. Currently, liver transplantation is the only definitive treatment for these patients and new therapies aiming to treat ALF\ninclude artificial organs implant and stem cells therapy, for example. However, a major limitation of liver donors exists. Living\ndonor liver transplantation (......), split liver transplantation (SLT), and domino liver transplantation (DLT) are some of the\navailable alternatives to treat ALF patients, but these do not reduce the number of patients on waiting lists. Herein, we discuss\ndomino hepatocyte transplantation (DHT) using livers that would not meet transplantation criteria. Methods. We conducted a\nliterature search on PubMed/Medline using acute liver failure, liver transplantation, hepatocyte transplantation, and domino liver\ntransplantation as key words. Results. New sources of biochemically functional hepatocytes and therapeutic treatments, in parallel\nto organ transplantation,may improve liver injury recovery and decreasemortality rates.Moreover, the literature reports hepatocyte\ntransplantation as a therapeutic alternative for organ shortage. However, a major challenge remains for a wide clinical application\nof hepatocytes therapy, i.e., the availability of sufficient amounts of cells for transplantation. Ideally, hepatocytes isolated fromlivers\nrejected for transplantation may be a promising alternative for this problem. Conclusion. Our review suggests that DHT may be an\nexcellent strategy to increase cell supplies for hepatocyte transplantation.
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